Psychosomatics 10: 193-197, 1969
Copyright
© 1969 Academy of Psychosomatic Medicine
The Differential Prediction of Response to Two Anti-Psychotic Drugs
B. J. GOLDSTEIN M.D.1,
B. BRAUZER M.D.1,
D. J. CLYDE Ph.D.1, , and
J. M. CALDWELL M.D.1
1 From the Department of Psychiatry, Division of Research, University of Miami School of Medicine, Miami, Florida
1. Both haloperidol and perphenazine are equally efficacious after 5 weeks of treatment.
2. Two successive treatments with haloperidol and perphenazine is no better or worse, after 10 weeks of treatment, than treatment with either drug alone for 10 weeks.
3. One can predict to the .03 level of significance who will respond after 5 weeks of treatment.
4. One can find subtle differences in the effects of each drug on groups of factors. These differential effects occur to the .02 level of significance. It is greater than a chance difference but at this time of questionable practical clinical value in predicting which drug is best for presenting symptoms.
It will be of interest to see if the levels of significance change with the addition of the WBRS data.
After the analysis is complete we hope to test the predictor factors directly in a double blind study utilizing three drugs and randomly assigning patients to the best and worst treatment.
